Adverse Skin Reactions with Antiepileptic Drugs Using Korea Adverse Event Reporting System Database, 2008–2017 | Zendy

Hyun Kyung Kim | Zendy; Dae Yeon Kim | Zendy; EunKee Bae | Zendy; Dong Wook Kim | Zendy

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Adverse Skin Reactions with Antiepileptic Drugs Using Korea Adverse Event Reporting System Database, 2008–2017

Author(s) -

Hyun Kyung Kim,

Dae Yeon Kim,

EunKee Bae,

Dong Wook Kim

Publication year - 2019

Publication title -

journal of korean medical science

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.743

H-Index - 66

eISSN - 1598-6357

pISSN - 1011-8934

DOI - 10.3346/jkms.2020.35.e17

Subject(s) - lamotrigine , medicine , carbamazepine , oxcarbazepine , toxic epidermal necrolysis , phenytoin , valproic acid , levetiracetam , rash , lacosamide , epilepsy , adverse effect , pharmacovigilance , drug eruption , dermatology , drug , pediatrics , pharmacology , psychiatry

Although most cutaneous drug eruptions in this study were rash or urticaria, approximately 8% of reports were of severe or life-threatening adverse drug reactions, such as SJS, TEN, or DRESS. When hypersensitivity skin reactions occurred, aromatic AEDs were associated with 4 fold the risk of SJS/TEN/DRESS compared with non-aromatic AEDs. Our findings further emphasize that high risk AEDs should be prescribed under careful monitoring, and early detection and prompt interventions are needed to prevent severe complications.

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