Open AccessGeneralized Pustular Psoriasis and Hepatic Dysfunction Associated with Oral Terbinafine Therapy
Author(s) -
Byung Soo Kim,
Ho Sun Jang,
Seung Wook Jwa,
Bong Seok Jang,
Moon Bum Kim,
ChangKeun Oh,
Yoo Wook Kwon,
KyungSool Kwon
Publication year - 2007
Publication title -
journal of korean medical science/journal of korean medical science
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.743
H-Index - 66
eISSN - 1598-6357
pISSN - 1011-8934
DOI - 10.3346/jkms.2007.22.1.167
Subject(s) - terbinafine , generalized pustular psoriasis , psoriasis , medicine , pustular psoriasis , dermatology , erythroderma , discontinuation , calcipotriol , itraconazole , antifungal
We report a case of 61-yr-old man with stable psoriasis who progressively developed generalized pustular eruption, erythroderma, fever, and hepatic dysfunction following oral terbinafine. Skin biopsy was compatible with pustular psoriasis. After discontinuation of terbinafine and initiating topical corticosteroid and calcipotriol combination with narrow band ultraviolet B therapy, patient's condition slowly improved until complete remission was reached 2 weeks later. The diagnosis of generalized pustular psoriasis (GPP) induced by oral terbinafine was made. To our knowledge, this is the first report of GPP accompanied by hepatic dysfunction associated with oral terbinafine therapy.