Lipid emulsion inhibits vasodilation induced by a toxic dose of bupivacaine by suppressing bupivacaine-induced PKC and CPI-17 dephosphorylation but has no effect on vasodilation induced by a toxic dose of mepivacaine | Zendy

Hyunhoo Cho | Zendy; Seong Ho Ok | Zendy; Seong Chun Kwon | Zendy; Soo Hee Lee | Zendy; Jiseok Baik | Zendy; Sebin Kang | Zendy; Jiah Oh | Zendy; JuTae Sohn | Zendy

Open Access

Lipid emulsion inhibits vasodilation induced by a toxic dose of bupivacaine by suppressing bupivacaine-induced PKC and CPI-17 dephosphorylation but has no effect on vasodilation induced by a toxic dose of mepivacaine

Author(s) -

Hyunhoo Cho,

Seong Ho Ok,

Seong Chun Kwon,

Soo Hee Lee,

Jiseok Baik,

Sebin Kang,

Jiah Oh,

JuTae Sohn

Publication year - 2016

Publication title -

the korean journal of pain

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.527

H-Index - 22

eISSN - 2093-0569

pISSN - 2005-9159

DOI - 10.3344/kjp.2016.29.4.229

Subject(s) - protein kinase c , bupivacaine , vasodilation , phorbol , pharmacology , dephosphorylation , medicine , mepivacaine , endocrinology , phosphorylation , chemistry , biochemistry , phosphatase

The goal of this in vitro study was to investigate the effect of lipid emulsion on vasodilation caused by toxic doses of bupivacaine and mepivacaine during contraction induced by a protein kinase C (PKC) activator, phorbol 12,13-dibutyrate (PDBu), in an isolated endothelium-denuded rat aorta.

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