Biphenotypic Acute Leukemia withBCR-ABLmRNA Transcript b3a2 Type: A Case Report with Review of the Literature | Zendy

Hyun-Woo Choi | Zendy; MyungGeun Shin | Zendy; Hyeoung-Joon Kim | Zendy; Il-Kwon Lee | Zendy; Ju-Hyun Yun | Zendy; Hye Ran Kim | Zendy; Yeo-Kyeoung Kim | Zendy; Hyeong-Kee Yun | Zendy; Duck Cho | Zendy; SeungJung Kee | Zendy; Jong Hee Shin | Zendy; SoonPal Suh | Zendy; DongWook Ryang | Zendy

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Biphenotypic Acute Leukemia withBCR-ABLmRNA Transcript b3a2 Type: A Case Report with Review of the Literature

Author(s) -

Hyun-Woo Choi,

MyungGeun Shin,

Hyeoung-Joon Kim,

Il-Kwon Lee,

Ju-Hyun Yun,

Hye Ran Kim,

Yeo-Kyeoung Kim,

Hyeong-Kee Yun,

Duck Cho,

SeungJung Kee,

Jong Hee Shin,

SoonPal Suh,

DongWook Ryang

Publication year - 2006

Publication title -

annals of laboratory medicine

Language(s) - English

Resource type - Journals

eISSN - 2234-3814

pISSN - 2234-3806

DOI - 10.3343/kjlm.2006.26.4.249

Subject(s) - theology , medicine , microbiology and biotechnology , philosophy , biology

Biphenotypic acute leukemia (BAL) is a subtype of leukemia of ambiguous lineage in the World Health Organization classification system. About one third of the cases have the Philadelphia chromosome, and some cases are associated with other structural abnormalities involving 11q23. BAL is known to have a poor prognosis in both children and adults. According to the previously reported BAL cases with positive BCR-ABL fusion gene, most of the BCR-ABL mRNA transcript type was e1a2. So, we describe here a 30-year-old adult BAL case with the karyotype 46,XY,t(9;22)(q34;q11.2) resulting in a very rare b3a2 type of BCR-ABL mRNA transcript.

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