FLT3 Gene Mutations as a Prognostic Factor for Acute Myeloid Leukemia | Zendy

Soon Hee Chang | Zendy; Nan Young Lee | Zendy; DongHwan Kim | Zendy; Sang Kyun Sohn | Zendy; Jang Soo Suh | Zendy

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FLT3 Gene Mutations as a Prognostic Factor for Acute Myeloid Leukemia

Author(s) -

Soon Hee Chang,

Nan Young Lee,

DongHwan Kim,

Sang Kyun Sohn,

Jang Soo Suh

Publication year - 2006

Publication title -

annals of laboratory medicine

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.784

H-Index - 34

eISSN - 2234-3814

pISSN - 2234-3806

DOI - 10.3343/kjlm.2006.26.4.233

Subject(s) - myeloid leukemia , biology , gene , mutation , gene duplication , cancer research , fms like tyrosine kinase 3 , gene mutation , leukemia , medicine , restriction fragment length polymorphism , polymerase chain reaction , lactate dehydrogenase , oncology , genetics , enzyme , biochemistry

Two distinct types of fms-like tyrosine kinase 3 (FLT3) gene mutations have been identified in acute myeloid leukemia (AML): D835 and internal tandem duplication (ITD) mutations. These mutations are known to cause the proliferation of leukemic cells and inhibit the apoptosis of leukemic cells due to ligand-independent activation of their receptors. Therefore, the current study attempted to investigate the frequency of FLT3 gene mutations and their prognostic implications for AML in terms of treatment response, survival, and relapse.

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