Association of NQO1 Polymorphism with Multiple Myeloma Risk in Koreans | Zendy

Seong-Ho Kang | Zendy; Tae Young Kim | Zendy; HoYoung Kim | Zendy; Yun Kyung Lee | Zendy; Hee Won Moon | Zendy; Dong Soon Lee | Zendy; Yunjung Cho | Zendy

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Association of NQO1 Polymorphism with Multiple Myeloma Risk in Koreans

Author(s) -

Seong-Ho Kang,

Tae Young Kim,

HoYoung Kim,

Yun Kyung Lee,

Hee Won Moon,

Dong Soon Lee,

Yunjung Cho

Publication year - 2006

Publication title -

annals of laboratory medicine

Language(s) - English

Resource type - Journals

eISSN - 2234-3814

pISSN - 2234-3806

DOI - 10.3343/kjlm.2006.26.2.71

Subject(s) - multiple myeloma , medicine , genotype , odds ratio , gastroenterology , immunology , oncology , biology , genetics , gene

NAD(P)H:quinone oxidoreductase 1 (NQO1) is an important enzyme in the metabolism of xenobiotics. NQO1 (609)C --> T (NQO1*2) has been reported to be associated with reduced enzyme activity, benzene-induced hematotoxicity, and acute leukemia. Incidences of multiple myeloma show interethnic variation and exposure to asbestos, petroleum products, and diesel exhaust is a risk factor for multiple myeloma. We studied the associations of NQO1 polymorphism with multiple myeloma risk, stage, and prognostic factors (hemoglobin, calcium, beta(2)-microglobulin, M-protein and creatinine).

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