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Cholera is an infectious disease acute intestinal tract and caused bybacteria Vibrio cholerae. If this bacteria contaminates food and is consumed in large amounts, it can cause diarrhea. Efforts to prevent diarrhea, which is one alternative to overcome antibiotic resistance that has the potential to treat diarrhea, is the skin of red pomegranates. The aim of the study was to determine the effect of red pomegranate skin extract and effective concentration of red pomegranate peel extract on the growth of Vibrio cholerae. Antibacterial test is done by paper disk diffusion method. The method used in this research is the experimental method, which consists of 5 treatments A0 = 0 (control), A1 = 25 mg / ml, A2 = 50 mg / ml, A3 = 75 mg / ml and A4 = 100 mg / ml and 3 repetitions. Observations were statistically analyzed usinganalysis one-way ANOVA with a significance level of 5%. Statistical analysis was performed using the SPSS version 16.0 program. The results showed that the effect of red pomegranate peel extract ongrowth Vibrio cholera and effective concentration of 100 mg / ml and can be seen at a significant value shows 0.00 in this case smaller than 0.05 (0.00≤0.005) which means there is a difference between the control with the treatment of A1, A2, A3 and A4. So that is evidenced by the formation of the average diameter of the clear zone at each concentration of red pomegranate skin extract, respectively: 25 mg / ml = 6.7 mm, 50 mg / ml = 7.3 mm, 75 mg / ml = 8 , 0 mm and 100 mg / ml = 11.3 mm.

UJI AKTIVITAS ANTIBAKTERI EKSTRAK KULIT BUAH DELIMA MERAH (Punica granatum L.) TERHADAP PERTUMBUHAN (Vibrio cholera)