Formulation and Evaluation of Transdermal Films of Salbutamol Sulphate | Zendy

YS Tanwar | Zendy

AI Assistant Blog Pricing

Home ZAIA Blog

Open Access

Formulation and Evaluation of Transdermal Films of Salbutamol Sulphate

Author(s) -

YS Tanwar

Publication year - 1970

Publication title -

dhaka university journal of pharmaceutical sciences

Language(s) - English

Resource type - Journals

eISSN - 1816-1839

pISSN - 1816-1820

DOI - 10.3329/dujps.v4i2.208

Subject(s) - permeation , transdermal , plasticizer , chemistry , solvent , salbutamol , polyvinyl alcohol , chromatography , peg 400 , peg ratio , solubility , guinea pig , nuclear chemistry , pig skin , pharmacology , polyethylene glycol , organic chemistry , medicine , biochemistry , asthma , food science , finance , membrane , economics

Transdermal drug delivery systems of salbutamol sulphate using eudragit RL100 and PVP were developed by solvent casting technique employing mercury as a substrate. Propylene glycol was used as a plasticizer. The prepared films exhibited satisfactory physico-chemical characteristics. In vitro permeation profiles across the guinea-pig dorsal skin using K-C diffusion cell are reported. Incorporating PEG-400 and tween 60 into the films enhanced the permeation across guinea-pig skin; permeation rate was greater with films containing PEG-400. The permeation followed zero order kinetics and mechanism was found to be matrix diffusion. Key words: Salbutamol sulphate, Guinea pig skin, Permeation enhancer. Dhaka Univ. J. Pharm. Sci. Vol.4(2) 2005 The full text is of this article is available at the Dhaka Univ. J. Pharm. Sci. website

The content you want is available to Zendy users.

Already have an account? Click here to sign in.

Having issues? You can contact us here

Accelerating Research