Effects of hypericin on the oxidative stress and modulation of cytochrome P450 (CYP1A) activity in microsomes | Zendy

Renata  Kubínová | Zendy; Václav  Suchý | Zendy; Marie  Valentová | Zendy

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Effects of hypericin on the oxidative stress and modulation of cytochrome P450 (CYP1A) activity in microsomes

Author(s) -

Renata Kubínová,

Václav Suchý,

Marie Valentová

Publication year - 2015

Publication title -

biomaterials and tissue engineering bulletin

Language(s) - English

Resource type - Journals

ISSN - 2393-0586

DOI - 10.33263/bteb214.024027

Subject(s) - hypericin , microsome , lucigenin , chemistry , lipid peroxidation , oxidative stress , cytochrome p450 , carcinogen , cytochrome , biochemistry , pharmacology , in vitro , enzyme , biology , superoxide

Hypericin is a pigment present in the widely distributed medicinal plant Hypericum perforatum L. (Hypericaceae). In our research, hypericin was found to be an inhibitor of NADPH/Fe 2+ induced microsomal lipid peroxidation and NADPH-dependent lucigenin chemiluminescence emission in vitro. Hypericin also inhibited the microsomal CYP1Adependent 7-ethoxyresorufin O-deethylase (EROD) which participates in the metabolic activation of xenobiotics including chemical carcinogens.

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