A bioluminescence imaging based in vivo model for preclinical testing of novel cellular immunotherapy strategies to improve the graft-versus-myeloma effect | Zendy

Henk Rozemuller | Zendy; Ellen van der Spek | Zendy; Lijnie Bogers-Boer | Zendy; M. C. Zwart | Zendy; Viviènne Verweij | Zendy; Maarten E. Emmelot | Zendy; Richard W.J. Groen | Zendy; Robbert M. Spaapen | Zendy; A C Bloem | Zendy; H M Lokhorst | Zendy; Tuna Mutis | Zendy; Anton C. Martens | Zendy

Open Access

A bioluminescence imaging based in vivo model for preclinical testing of novel cellular immunotherapy strategies to improve the graft-versus-myeloma effect

Author(s) -

Henk Rozemuller,

Ellen van der Spek,

Lijnie Bogers-Boer,

M. C. Zwart,

Viviènne Verweij,

Maarten E. Emmelot,

Richard W.J. Groen,

Robbert M. Spaapen,

A C Bloem,

H M Lokhorst,

Tuna Mutis,

Anton C. Martens

Publication year - 2008

Publication title -

haematologica

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.782

H-Index - 142

eISSN - 1592-8721

pISSN - 0390-6078

DOI - 10.3324/haematol.12349

Subject(s) - multiple myeloma , medicine , bioluminescence imaging , bone marrow , cancer research , immunotherapy , peripheral blood mononuclear cell , in vivo , immunoglobulin light chain , pathology , luciferase , immune system , cell culture , immunology , in vitro , biology , antibody , transfection , biochemistry , microbiology and biotechnology , genetics

The development and preclinical testing of novel immunotherapy strategies for multiple myeloma can benefit substantially from a humanized animal model that enables quantitative real-time monitoring of tumor progression. Here we have explored the feasibility of establishing such a model in immunodeficient RAG2(-/-)gammac(-/-) mice, by utilizing non-invasive bioluminescent imaging for real-time monitoring of multiple myeloma cell growth.

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