Renal targeting of captopril using captopril-lysozyme conjugate enhances its antiproteinuric effect in adriamycin-induced nephrosis | Zendy

Willemijn AKM Windt | Zendy; Jai Prakash | Zendy; Robbert J. Kok | Zendy; Frits Moolenaar | Zendy; C. Alex Kluppel | Zendy; Dick de Zeeuw | Zendy; Richard PE van Dokkum | Zendy; Robert H. Henning | Zendy

Open Access

Renal targeting of captopril using captopril-lysozyme conjugate enhances its antiproteinuric effect in adriamycin-induced nephrosis

Author(s) -

Willemijn AKM Windt,

Jai Prakash,

Robbert J. Kok,

Frits Moolenaar,

C. Alex Kluppel,

Dick de Zeeuw,

Richard PE van Dokkum,

Robert H. Henning

Publication year - 2004

Publication title -

journal of the renin-angiotensin-aldosterone system

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.457

H-Index - 46

eISSN - 1752-8976

pISSN - 1470-3203

DOI - 10.3317/jraas.2004.040

Subject(s) - captopril , proteinuria , lysozyme , angiotensin converting enzyme , endocrinology , ace inhibitor , medicine , pharmacology , chemistry , nephrosis , kidney , blood pressure , biochemistry

High-sodium intake blunts the renoprotective efficacy of angiotensin-converting enzyme (ACE) inhibitors. We investigated whether targeting the drug to the kidneys may attenuate the inferior response to ACE inhibitor (ACE-I) under high-sodium conditions. The ACE-I, captopril, was coupled to the low molecular weight protein (LMWP) lysozyme, yielding captopril-lysozyme conjugates that accumulate specifically in the proximal tubular cells of the kidneys. We compared the antiproteinuric efficacy of captopril to that of the captopril-lysozyme conjugate in adriamycin-induced proteinuric rats fed with a high-sodium diet.

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