Open AccessElevated dietary sodium intake exacerbates myocardial hypertrophy associated with cardiac-specific overproduction of angiotensin II
Author(s) -
Enzo R. Porrello,
Catherine E. Huggins,
Claire L. Curl,
Andrea A. Domenighetti,
Thierry Pedrazzini,
L. Delbridge,
Trefor Morgan
Publication year - 2004
Publication title -
jraas. journal of the renin-angiotensin-aldosterone system/journal of the renin-angiotensin-aldosterone system
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.457
H-Index - 46
eISSN - 1752-8976
pISSN - 1470-3203
DOI - 10.3317/jraas.2004.036
Subject(s) - medicine , endocrinology , angiotensin ii , muscle hypertrophy , sodium , renin–angiotensin system , receptor , cardiac hypertrophy , biology , chemistry , blood pressure , organic chemistry
Cardiac hypertrophy is an independent risk factor predictive of cardiovascular disease and is significantly associated with morbidity and mortality. The mechanism by which angiotensin II (Ang II) and dietary sodium exert additive effects on the development of cardiac hypertrophy is unclear. The goal of this study was to evaluate the hypothesis that, where there is a genetic predisposition to Ang II-dependent hypertrophy, there is also an increased susceptibility to sodium-induced hypertrophy mediated by AT1-receptor expression.