Open AccessRegulation of renal proximal fluid uptake by luminal and peritubular angiotensin II
Author(s) -
Siriphun Hiranyachattada,
Peter Harris
Publication year - 2004
Publication title -
jraas. journal of the renin-angiotensin-aldosterone system/journal of the renin-angiotensin-aldosterone system
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.457
H-Index - 46
eISSN - 1752-8976
pISSN - 1470-3203
DOI - 10.3317/jraas.2004.016
Subject(s) - peritubular capillaries , angiotensin ii , medicine , lumen (anatomy) , endocrinology , chemistry , candesartan , tubular fluid , kidney , proximal tubule , circulatory system , receptor , renin–angiotensin system , biology , blood pressure
Angiotensin II (Ang II), when administered to either tubular lumen or peritubular capillary, exerts a biphasic action on proximal fluid uptake rate. At low concentrations, (10 -12 —10 -10 M) Ang II stimulates fluid transport, whereas higher doses (> 10 -9 M) inhibit. Ang II is secreted into the lumen in the proximal tubule and the concentration of Ang II in the proximal lumen has been reported to be in the nanomolar range, 100—1,000 times higher than in peritubular blood. We investigated the regulation of renal proximal fluid transport by luminal (predominantly locally produced) and peritubular capillary (circulatory) Ang II in anaesthetised rats, using a selective AT 1 -receptor antagonist, candesartan.