Angiotensin-converting enzyme DD genotype in patients with primary pulmonary hypertension: increased frequency and association with preserved haemodynamics | Zendy

William T. Abraham | Zendy; Mary V. Raynolds | Zendy; David B. Badesch | Zendy; Kristine Wynne | Zendy; Bertron Μ. Groves | Zendy; Robert L. Roden | Zendy; A. Robertson | Zendy; Brian D. Lowes | Zendy; Lawrence S. Zisman | Zendy; Norbert F. Voelkel | Zendy; Michael R. Bristow | Zendy; M. Benjamin Perryman | Zendy

Open Access

Angiotensin-converting enzyme DD genotype in patients with primary pulmonary hypertension: increased frequency and association with preserved haemodynamics

Author(s) -

William T. Abraham,

Mary V. Raynolds,

David B. Badesch,

Kristine Wynne,

Bertron Μ. Groves,

Robert L. Roden,

A. Robertson,

Brian D. Lowes,

Lawrence S. Zisman,

Norbert F. Voelkel,

Michael R. Bristow,

M. Benjamin Perryman

Publication year - 2003

Publication title -

journal of the renin-angiotensin-aldosterone system

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.457

H-Index - 46

eISSN - 1752-8976

pISSN - 1470-3203

DOI - 10.3317/jraas.2003.003

Subject(s) - medicine , hemodynamics , cardiology , pulmonary hypertension , genotype , angiotensin converting enzyme , angiotensin ii , renin–angiotensin system , blood pressure , pulmonary artery , endocrinology , biology , genetics , gene

HYPOTHESIS/INTRODUCTION: A polymorphic marker within the angiotensin- converting enzyme (ACE) gene has been associated with circulating and tissue ACE activity and with a variety of forms of cardiovascular disease. Since angiotensin II (Ang II) causes pulmonary vasoconstriction and vascular and myocardial remodelling, we postulated a role for the renin-angiotensin system and the ACE DD genotype in the pathophysiology of primary pulmonary hypertension (PPH) and in the right ventricular response to pressure overload in these patients.

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