Effects of losartan on haemodynamic parameters and angiotensin receptor mRNA levels in rat heart after myocardial infarction | Zendy

Yi Zhun Zhu | Zendy; YiChun Zhu | Zendy; Jun Li | Zendy; H. Schäfer | Zendy; Wolfgang Schmidt | Zendy; Tai Yao | Zendy; Thomas Unger | Zendy

Open Access

Effects of losartan on haemodynamic parameters and angiotensin receptor mRNA levels in rat heart after myocardial infarction

Author(s) -

Yi Zhun Zhu,

YiChun Zhu,

Jun Li,

H. Schäfer,

Wolfgang Schmidt,

Tai Yao,

Thomas Unger

Publication year - 2000

Publication title -

journal of the renin-angiotensin-aldosterone system

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.457

H-Index - 46

eISSN - 1752-8976

pISSN - 1470-3203

DOI - 10.3317/jraas.2000.039

Subject(s) - losartan , myocardial infarction , cardiology , medicine , hemodynamics , angiotensin ii , receptor

We investigated the haemodynamic parameters and the regulation of cardiac mRNA levels of the angiotensin receptor subtypes, AT 1 and AT 2 , by the AT 1 -receptor antagonist losartan in rat heart during the acute phase of myocardial infarction. AT 1 - and AT 2 -receptor mRNA levels markedly increased at 30 minutes and peaked at 24 hours post myocardial infarction (12.6-fold increase for AT 1 - and 17.2-fold increase for AT 2 compared with controls). Losartan significantly reduced mean blood pressure in sham-operated rats and decreased mean blood pressure and left ventricular end-diastolic pressure in myocardial infarction rats. However, the AT 1 - and AT 2 -receptor mRNA levels of losartan-treated rats showed a pattern similar to that of water-treated rats. The time-dependent increase of AT 1 - and AT 2 receptor mRNA levels is associated with the early remodelling process of non-infarcted myocardium post MI and is independent of AT 1 -receptor blockade.

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