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We investigated the haemodynamic parameters and the regulation of cardiac mRNA levels of the angiotensin receptor subtypes, AT 1  and AT 2 , by the AT 1 -receptor antagonist losartan in rat heart during the acute phase of myocardial infarction. AT 1 - and AT 2 -receptor mRNA levels markedly increased at 30 minutes and peaked at 24 hours post myocardial infarction (12.6-fold increase for AT 1 - and 17.2-fold increase for AT 2  compared with controls). Losartan significantly reduced mean blood pressure in sham-operated rats and decreased mean blood pressure and left ventricular end-diastolic pressure in myocardial infarction rats. However, the AT 1 - and AT 2 -receptor mRNA levels of losartan-treated rats showed a pattern similar to that of water-treated rats. The time-dependent increase of AT  1 - and AT 2 receptor mRNA levels is associated with the early remodelling process of non-infarcted myocardium post MI and is independent of AT 1 -receptor blockade.

Effects of losartan on haemodynamic parameters and angiotensin receptor mRNA levels in rat heart after myocardial infarction