Mechanical strain-induced human vascular matrix synthesis: The role of angiotensin II | Zendy

Adrian G. Stanley | Zendy; Hash Patel | Zendy; Abigail L Knight | Zendy; Bryan Williams | Zendy

AI Assistant Blog Pricing

Home ZAIA Blog

Open Access

Mechanical strain-induced human vascular matrix synthesis: The role of angiotensin II

Author(s) -

Adrian G. Stanley,

Hash Patel,

Abigail L Knight,

Bryan Williams

Publication year - 2000

Publication title -

journal of the renin-angiotensin-aldosterone system

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.457

H-Index - 46

eISSN - 1752-8976

pISSN - 1470-3203

DOI - 10.3317/jraas.2000.007

Subject(s) - fibronectin , losartan , angiotensin ii , receptor , chemistry , vascular smooth muscle , endocrinology , medicine , matrix (chemical analysis) , messenger rna , microbiology and biotechnology , receptor antagonist , extracellular matrix , antagonist , biology , biochemistry , smooth muscle , gene , chromatography

Reduced vascular compliance in patients with hypertension results from an increase in extra-cellular matrix (ECM) protein deposition in blood vessels. At least two key factors, namely mechanical strain and neurohumoral mediators, for example Angiotensin II (Ang II), promote fibrogenesis within vessel walls; however potential interactions between these have not been clearly defined. This work examined the direct effect of mechanical strain on matrix mRNA expression and protein synthesis by human vascular smooth muscle (VSM) cells and identified the importance of renin-angiotensin system (RAS) activation in stretch-induced matrix production.

The content you want is available to Zendy users.

Already have an account? Click here to sign in.

Having issues? You can contact us here

Accelerating Research