Cutaneous squamous cell carcinoma: High risk factors, staging and management

Cutaneous squamous cell carconoma(cSCC) is a malignant neoplasm derived from suprabasal epidermal keratinocytes, which is one of the nonmelanoma skin cancers that represent the most common malignancies in humans. Although most of cSCCs are small low-risk cancers easily treated by minor surgical procedures, some cSCCs continue to grow to be invasive SCC. They can cause not only significant morbidity and cosmetic deformity but also even metastases and death. In leprosy, chronic, recurrent ulceration and resultant scars associated with peripheral neuropathy are one of the main complications, which can give rise to cSCCs. The primary goal of cSCC treatment is complete tumor eradication with preservation of function and good cosmesis. However, prior to treatment, the preoperative workup is performed properly and tumor risk factors influencing on the treatment and prognosis are taken into consideration.