First and second trimester antenatal screening for Down's syndrome: the results of the Serum, Urine and Ultrasound Screening Study (SURUSS) | Zendy

Nicholas Wald | Zendy; Charles H. Rodeck | Zendy; Allan Hackshaw | Zendy; Jocelyn Walters | Zendy; Lyn S. Chitty | Zendy; AM. Mackinson | Zendy

Open Access

First and second trimester antenatal screening for Down's syndrome: the results of the Serum, Urine and Ultrasound Screening Study (SURUSS)

Author(s) -

Nicholas Wald,

Charles H. Rodeck,

Allan Hackshaw,

Jocelyn Walters,

Lyn S. Chitty,

AM. Mackinson

Publication year - 2003

Publication title -

health technology assessment

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.426

H-Index - 126

eISSN - 2046-4924

pISSN - 1366-5278

DOI - 10.3310/hta7110

Subject(s) - medicine , obstetrics , ultrasound , gestation , gynecology , pregnancy , urine , radiology , endocrinology , biology , genetics

The matching criteria were gestation (using an ultrasound crown–rump length or biparietal diameter measurement), duration of storage, and centre. Screening performance of the individual markers and combinations of markers together with maternal age was assessed using standard methods. In addition pairs of first and second trimester serum samples from 600 controls were tested to secure a larger set in which screening performance could be deter mined using distribution parameters based on dates (time since first day of the last menstrual period).

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