DiPALS: Diaphragm Pacing in patients with Amyotrophic Lateral Sclerosis – a randomised controlled trial
Author(s) -
Christopher McDermott,
Mike Bradburn,
Chin Maguire,
Cindy Cooper,
Wendy Baird,
Susan Baxter,
Judith Cohen,
Hannah Cantrill,
Simon Dixon,
Roger Ackroyd,
Simon Baudouin,
Andrew Bentley,
Richard Berrisford,
Stephen Bianchi,
Stephen C Bourke,
Roy Darlison,
John Ealing,
Mark Elliott,
Patrick Fitzgerald,
Simon Galloway,
Hisham Hamdalla,
C. Oliver Hanemann,
Philip Hughes,
Ibrahim Imam,
Dayalan Karat,
Roger Leek,
Nick Maynard,
Richard W. Orrell,
Abeezar Sarela,
John Stradling,
Kevin Talbot,
Lyn Taylor,
Martin R. Turner,
Anita K. Simonds,
Timothy L. Williams,
Wisia Wedzicha,
Carolyn Young,
Pamela J. Shaw
Publication year - 2016
Publication title -
health technology assessment
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.426
H-Index - 126
eISSN - 2046-4924
pISSN - 1366-5278
DOI - 10.3310/hta20450
Subject(s) - medicine , amyotrophic lateral sclerosis , randomized controlled trial , diaphragm (acoustics) , surgery , disease , physics , acoustics , loudspeaker
Amyotrophic lateral sclerosis (ALS) is a neurodegenerative disease resulting in death, usually from respiratory failure, within 2-3 years of symptom onset. Non-invasive ventilation (NIV) is a treatment that when given to patients in respiratory failure leads to improved survival and quality of life. Diaphragm pacing (DP), using the NeuRx/4(®) diaphragm pacing system (DPS)™ (Synapse Biomedical, Oberlin, OH, USA), is a new technique that may offer additional or alternative benefits to patients with ALS who are in respiratory failure.
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