A high-dose preparation of lactobacilli and bifidobacteria in the prevention of antibiotic-associated and Clostridium difficile diarrhoea in older people admitted to hospital: a multicentre, randomised, double-blind, placebo-controlled, parallel arm trial (PLACIDE) | Zendy

Stephen Allen | Zendy; K. Wareham | Zendy; D Wang | Zendy; Caroline Bradley | Zendy; Bernadette Sewell | Zendy; Hayley Hutchings | Zendy; W Harris | Zendy; Anjan Dhar | Zendy; Helga Brown | Zendy; A Foden | Zendy; MB Gravenor | Zendy; Damien Mack | Zendy; Ceri Phillips | Zendy

Open Access

A high-dose preparation of lactobacilli and bifidobacteria in the prevention of antibiotic-associated and Clostridium difficile diarrhoea in older people admitted to hospital: a multicentre, randomised, double-blind, placebo-controlled, parallel arm trial (PLACIDE)

Author(s) -

Stephen Allen,

K. Wareham,

D Wang,

Caroline Bradley,

Bernadette Sewell,

Hayley Hutchings,

W Harris,

Anjan Dhar,

Helga Brown,

A Foden,

MB Gravenor,

Damien Mack,

Ceri Phillips

Publication year - 2013

Publication title -

health technology assessment

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.426

H-Index - 126

eISSN - 2046-4924

pISSN - 1366-5278

DOI - 10.3310/hta17570

Subject(s) - medicine , placebo , clostridium difficile , probiotic , antibiotics , adverse effect , placebo controlled study , randomized controlled trial , diarrhea , pediatrics , double blind , microbiology and biotechnology , genetics , alternative medicine , pathology , bacteria , biology

Antibiotic-associated diarrhoea (AAD) occurs most commonly in older people admitted to hospital and within 12 weeks of exposure to broad-spectrum antibiotics. Although usually a mild and self-limiting illness, the 15-39% of cases caused by Clostridium difficile infection [C. difficile diarrhoea (CDD)] may result in severe diarrhoea and death. Previous research has shown that probiotics, live microbial organisms that, when administered in adequate numbers, are beneficial to health, may be effective in preventing AAD and CDD.

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