Study of the use of antidepressants for depression in dementia: the HTA-SADD trial – a multicentre, randomised, double-blind, placebo-controlled trial of the clinical effectiveness and cost-effectiveness of sertraline and mirtazapine | Zendy

Sube Banerjee | Zendy; Jennifer Hellier | Zendy; Renée Romeo | Zendy; Michael Dewey | Zendy; Martín Knapp | Zendy; Clive Ballard | Zendy; R Baldwin | Zendy; Peter Bentham | Zendy; Chris Fox | Zendy; Clive Holmes | Zendy; Cornelius Katona | Zendy; Claire Lawton | Zendy; James Lindesay | Zendy; Gill Livingston | Zendy; Niall McCrae | Zendy; Esme MonizCook | Zendy; Joanna Murray | Zendy; Shirley Nurock | Zendy; Martin Orrell | Zendy; John T. O’Brien | Zendy; Michaela Poppe | Zendy; Alan Thomas | Zendy; Rebecca Walwyn | Zendy; Ken Wilson | Zendy; Alistair Burns | Zendy

Open Access

Study of the use of antidepressants for depression in dementia: the HTA-SADD trial – a multicentre, randomised, double-blind, placebo-controlled trial of the clinical effectiveness and cost-effectiveness of sertraline and mirtazapine

Author(s) -

Sube Banerjee,

Jennifer Hellier,

Renée Romeo,

Michael Dewey,

Martín Knapp,

Clive Ballard,

R Baldwin,

Peter Bentham,

Chris Fox,

Clive Holmes,

Cornelius Katona,

Claire Lawton,

James Lindesay,

Gill Livingston,

Niall McCrae,

Esme MonizCook,

Joanna Murray,

Shirley Nurock,

Martin Orrell,

John T. O’Brien,

Michaela Poppe,

Alan Thomas,

Rebecca Walwyn,

Ken Wilson,

Alistair Burns

Publication year - 2013

Publication title -

health technology assessment

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.426

H-Index - 126

eISSN - 2046-4924

pISSN - 1366-5278

DOI - 10.3310/hta17070

Subject(s) - sertraline , mirtazapine , placebo , medicine , randomized controlled trial , clinical trial , psychiatry , dementia , psychology , antidepressant , anxiety , disease , alternative medicine , pathology

Depression is common in dementia, causing considerable distress and other negative impacts. Treating it is a clinical priority, but the evidence base is sparse and equivocal. This trial aimed to determine clinical effectiveness of sertraline and mirtazapine in reducing depression 13 weeks post randomisation compared with placebo.

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