Green Chemistry Synthesis of Five-Membered Heterocylic Derivatives (1, 3, 4-oxadizoles) by Using Grinding Technique

In this research we prepared about 28 derivatives of five-membered heterocyclic compounds (1,3,4-oxadizoles) in two lines , in the first line we used phenylhydrazide and in the second line we used 4-hydroxy phenylhydrazide as starting material for cyclization, By using eco–friendly efficient synthesis of oxadiazole derivatives through the reaction of aromatic hydrazide with different substituted aromatic aldehydes by grinding them in the presence of catalytical amounts of iodine.