Spectrophotometric Determination of Chlorpromazine Hydrochloride in Pharmaceutical Preparations by Oxidative Coupling reaction. | Zendy

Sunbul Anwar | Zendy

Open Access

Spectrophotometric Determination of Chlorpromazine Hydrochloride in Pharmaceutical Preparations by Oxidative Coupling reaction.

Author(s) -

Sunbul Anwar

Publication year - 2018

Publication title -

kirkuk university journal-scientific studies

Language(s) - English

Resource type - Journals

eISSN - 2616-6801

pISSN - 1992-0849

DOI - 10.32894/kujss.2018.13.3.3

Subject(s) - chemistry , molar absorptivity , hydrochloric acid , aniline , oxidative coupling of methane , ceric ammonium nitrate , hydrochloride , chromatography , absorption (acoustics) , spectrophotometry , dosage form , nuclear chemistry , organic chemistry , materials science , catalysis , physics , polymer , optics , composite material , grafting

An easy and simple spectrophotometric method was described for estimating chlorpromazine Hydrochloride drug in aqueous solution. Where The method was adopted on oxidative coupling reaction of the drug with pnitro aniline in the presence of ceric(IV) ammonium nitrate and hydrochloric acid solution an orange-brown product dye was obtainded with maximum absorption at 525 nm. with moler absorptivity of 9.24×10 l. mol. cm -1 and sandell's sensitivity of 0.0385 μg.cm Beer's law is obeyed over the concentration range of (12-46) μg.ml -1 . The method was applied successfully for the estimating the drug it's on pure condition or in pharmaceutical preparations (Largactil drug).

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