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espanolDebido al cuello de botella demografico, la poblacion actual de bisonte europeo muestra un elevado grado de endogamia y una perdida significativa de variabilidad genetica. Es necesario que en los estudios realizados con estas especies especificas se apliquen metodos que permitan obtener tanta informacion genomica como sea posible en un tiempo breve. El objetivo de este estudio era definir un conjunto de marcadores de tipo PSN (polimorfismo de un solo nucleotido) que pudiera servir para analizar la diversidad genetica de las dos lineas de bisontes europeos: Lowland (LB) y Lowland–Caucasiana (LC). En el estudio se analizaron 57 individuos de la linea LB y 72 de la linea LC. Para caracterizar bien el rendimiento de los PSN en el bisonte europeo, se usaron dos micromatrices multigenicas (genochip) con densidades diferentes de marcadores: BovineSNP50 v2 BeadChip y BovineHD BeadChip. Como consecuencia de los criterios adoptados, se seleccionaron 1.421 y 22.122 marcadores, respectivamente. Sobre la base del analisis estadistico (frecuencias alelicas, prueba exacta de Fisher y prueba Z), en ultima instancia se selecciono un conjunto de 1.536 marcadores informativos de PSN para los estudios adicionales, 26 de los cuales tienen alelos privados para LB y 611, para la linea LC. La informacion obtenida en este estudio podria enriquecer aun mas y apoyar a los programas de reproduccion en un contexto de parentesco entre especimenes particulares y manadas que viven en cautividad en centros reproductivos. EnglishAs the result of a population bottleneck, the present living population of European bison shows a high level of inbreeding, and a significant loss of genetic variability. In studies on such specific species there is a need to apply methods that obtain as much information about the genome as possible in a short time. The aim of the study was to define a panel of SNP (Single Nucleotide Polymorphism) markers that could serve in genetic diversity analysis of European bison from two lines: Lowland (LB) and Lowland–Caucasian (LC). The study used 57 individuals from the LB line and 72 from the LC line. To identify well–performing SNPs in European bison, we used two microarrays with different markers densities: BovineSNP50 v2 BeadChip and BovineHD BeadChip. As a result of the adopted criteria, 1,421 and 22,122 markers, respectively, were selected. On the basis of statistical analysis (allele frequencies, Fisher’s exact test, and the Z–test), a panel of 1,536 informative SNP markers was ultimately selected for further study; 26 of these with private alleles for the LB line and 611 with private alleles for the LC line. The data obtained in this study could further enrich and support breeding programs in the context of relatedness between particular specimens and herds from captive breeding centres.

Panel of informative SNP markers for two genetic lines of European bison: Lowland and Lowland–Caucasian