Synthesis and antiviral properties of 1-substituted 3-[ω-(4-oxoquinazolin-4(3h)-yl)alkyl]uracil derivatives | Zendy

Maria P. Paramonova | Zendy; Anastasia L. Khandazhinskaya | Zendy; А. А. Озеров | Zendy; Sergey N. Kochetkov | Zendy; Robert Snoeck | Zendy; Graciela Andreï | Zendy; Михаил С. Новиков | Zendy

AI Assistant Blog Pricing

Home ZAIA Blog

Open Access

Synthesis and antiviral properties of 1-substituted 3-[ω-(4-oxoquinazolin-4(3h)-yl)alkyl]uracil derivatives

Author(s) -

Maria P. Paramonova,

Anastasia L. Khandazhinskaya,

А. А. Озеров,

Sergey N. Kochetkov,

Robert Snoeck,

Graciela Andreï,

Михаил С. Новиков

Publication year - 2020

Publication title -

acta naturae

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.475

H-Index - 26

ISSN - 2075-8251

DOI - 10.32607/actanaturae.10983

Subject(s) - uracil , methylene bridge , pyrimidine , chemistry , alkyl , nitrogen atom , stereochemistry , varicella zoster virus , methylene , ring (chemistry) , inhibitory postsynaptic potential , virus , dna , virology , biochemistry , biology , medicinal chemistry , organic chemistry , neuroscience

A series of uracil derivatives containing a 4-oxoquinazoline fragment bound to the nitrogen atom N3 of the pyrimidine ring by a short methylene bridge was synthesized to search for new antiviral agents. Some compounds in this series are shown to exhibit high inhibitory activity against human cytomegalovirus and the varicella zoster virus in a HEL cell culture.

The content you want is available to Zendy users.

Already have an account? Click here to sign in.

Having issues? You can contact us here

Accelerating Research