Open AccessGlutamyl Endopeptidases: The Puzzle of Substrate Specificity
Author(s) -
Ilya V. Demidyuk,
Ksenia N. Chukhontseva,
Sergey V. Kostrov
Publication year - 2017
Publication title -
acta naturae
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.475
H-Index - 26
ISSN - 2075-8251
DOI - 10.32607/20758251-2017-9-2-17-33
Subject(s) - cleave , substrate specificity , enzyme , biochemistry , chymotrypsin , substrate (aquarium) , peptide , chemistry , stereochemistry , biology , trypsin , ecology
Glutamyl endopeptidases (GEPases) are chymotrypsin-like enzymes that preferentially cleave the peptide bonds of the -carboxyl groups of glutamic acid. Despite the many years of research, the structural determinants underlying the strong substrate specificity of GEPases still remain unclear. In this review, data concerning the molecular mechanisms that determine the substrate preference of GEPases is generalized. In addition, the biological functions of and modern trends in the research into these enzymes are outlined.