Brief Note: CD44 is involved in CXCL-12 induced acute myeloid leukemia HL-60 cell polarity | Zendy

LIPING ZHOU | Zendy; XIAOLIN GUO | Zendy; JING BA | Zendy; LIANSHUANG ZHA | Zendy

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Brief Note: CD44 is involved in CXCL-12 induced acute myeloid leukemia HL-60 cell polarity

Author(s) -

LIPING ZHOU,

XIAOLIN GUO,

JING BA,

LIANSHUANG ZHA

Publication year - 2010

Publication title -

biocell

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.182

H-Index - 27

eISSN - 1667-5746

pISSN - 0327-9545

DOI - 10.32604/biocell.2010.34.091

Subject(s) - cd44 , lymphocyte homing receptor , homing (biology) , cancer research , cxcr4 , myeloid leukemia , receptor , hyaluronic acid , cell adhesion , cell , immunology , medicine , biology , chemokine , biochemistry , genetics , ecology

CXCL-12 and its receptor CXCR4 participate in breast cancer and melanoma cell metastasis to bone and lymphoid nodes. CD44, as a receptor for hyaluronic acid, is involved in lymphocyte recirculation, homing, adhesion and migration. But the role of CD44 in CXCL-12 induced leukemia cell migration still remains unclear. The present study showed that CXCL-12 stimulation induced the rapid internalization of CXCR4 and facilitated the formation of lamellipodia and uropod in acute leukemia cell line HL-60. CXCL-12 also induced CD44 translocation into the uropod, while CD44 remained evenly distributed on the untreated cell membranes. Results suggest that CD44 participates in CXCL-12 induced cell polarization and subsequent cell migration.

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