Primordial Dwarfism: A Case Series From North East of Iran and Literature Review

Primordial dwarfism is a rare class of genetic disorders, characterized by intrauterine growth retardation, short stature at birth and growth deficiency that persist throughout life. This disorder is caused by various mechanisms such as chromosomal abnormalities, molecular changes and mutation of genes that result in developmental defects, facial dysmorphism and skeletal abnormalities in fetus. Primordial dwarfism includes 5 specific subtypes that their descriptions vary from one type to another. This study aimed to report 7 cases of primordial dwarfism as the first case series study and literature review of this disorder in Iran.