The Efficacy of Cinnamon Extract ( Cinnamomum burmannii ) on Reducing Staging Acute Kidney Injury in Ischemia Reperfusion (IR) Model

. Acute kidney injury (AKI) is defined as sudden decline in the glomerular filtration rate, resulting in the retention of nitrogenous wastes, such as urea and creatinine in plasma. Cinnamomum burmannii is known as a anti inflammatory renoprotective agent, although the precise mechanism is not well understood. This study aimed to elucidate the effectiveness of Cinnamomum burmannii extract in decreasing creatinine level of acute kidney injury Ischemia reperfusion (IR) model. Method. We performed Ischemia reperfusion (IR) in male Wistar rat to induce acute kidney injury. The rat (n=30) were divided into six groups: IR, 1 group treated with methylprednisolone as a control (IR+M), 3 groups treated with different oral Cinnamomum burmannii extract doses (50mg/kg (IR+EKM1), 100mg/kg (IR+EKM2), and 200 mg/kg (IR+EKM3), and a Sham operation (SO) group. AKI stage reduction based on serum creatinine levels, before and after modeling, before and after the cinnamon extract intervention. Creatinine levels were quntified by spectrophotometry and analyzed by SPSS. Result. Cinnamomum burmannii extract lowers creatinine levels; significant (P <0.05). 200 mg / kgbb is the effective dose of lowering creatinine levels in the IR model. Conclusion. Cinnamomum burmannii extract reduced serum creatinine levels associated with decreased acute renal staging in the IR model.