Comparison of Chest X-Ray Assessment in Multi-Drug Resistance to Drug- Sensitive Tuberculosis Patients

. Indonesia ranks third in tuberculosis cases, with 23,000 new dual drug-resistant tuberculosis patients. The delay in predicting tuberculosis resistance occurs because sputum tools are not yet available. This study aimed to determine the differences in chest x-rays for drug-sensitive multiple drug-resistant tuberculosis in Palembang. Method. A case-control design to compare the radiological characteristics of multiple drug resistance with drug-sensitive at Palembang during January-July 2020. One hundred thirty-eight patients consisted of cases of drug-sensitive tuberculosis and multidrug-resistant tuberculosis based on the rapid molecular test that met the inclusion criteria, analyzed for posteroanterior chest X-rays by a radiologist without knowing the diagnosis— comparative chi-square using SPSS 22. Result. Multidrug resistance tuberculosis had more extensive or moderate lesions than drug-sensitive tuberculosis 89.8% vs 72.4%. The multidrug-resistant group has more infiltrate detected, namely 84.1% vs 69.6% and cavity 37.6% vs 30.4%. Atelectasis and pleural effusion are common in drug-resistant tuberculosis. Bivariate analysis showed that multidrug-resistant tuberculosis lesion infiltrates compared to drug-sensitive tuberculosis with p = 0.025; OR 2,6 (CI 95% 1,1-6,0) sensitivity 85.5%, specificity 30.4%. Multivariate analysis showed the presence of infiltrates p = 0.028; OR 2.58 (CI 95% 1.1-6.003). Consolidation, nodules, cavities, fibrosis, atelectasis, pleural effusion were not significant differences in the two groups. Conclusion. Multidrug-resistant tuberculosis has a more expansive lesion, the presence of infiltrates and cavities that is more dominant than drug-sensitive tuberculosis.