Sarcopenia from Pathophysiology to Clinical : Literature Review | Zendy

Rachmat Hidayat | Zendy; Nur Riviati | Zendy

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Sarcopenia from Pathophysiology to Clinical : Literature Review

Author(s) -

Rachmat Hidayat,

Nur Riviati

Publication year - 2021

Publication title -

biomedical journal of indonesia

Language(s) - English

Resource type - Journals

eISSN - 2685-0184

pISSN - 2407-7097

DOI - 10.32539/bji.v7i1.261

Subject(s) - sarcopenia , mechanism (biology) , anabolism , pathophysiology , medicine , insulin resistance , inflammation , bioinformatics , endocrinology , diabetes mellitus , biology , philosophy , epistemology

A B S T R A C TThe causes of sarcopenia are thought to be multifactorial including: environmentalfactors, illness, activation of inflammatory pathways, mitochondrial dysfunction, lossof neuromuscular junctions, reduced number of satellite cells and changes in thequality of hormonal function. The mechanism of sarcopenia occurs because the agingprocess coupled with reduced physical activity can cause the formation of cytokinesto increase so that inflammation is easy, insulin resistant, anabolic resistance andneuromuscular impairments.

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