English (United Kingdom)

https://curated-unify.zendy.io/wp-json/zendy-region/v1/featured_content/oa?rat=en

https://curated-unify.zendy.io/wp-json/zendy-region/v1/highlighted_journal/

Global: Zendy Plus annual

Presents the access of premium content as premium feature

Premium Content

Presents the keyphrase highlighting as premium feature

Keyphrase Highlighting

Presents the summarisation as premium feature

Summarisation

Insights

Presents the pdf analysis as premium feature

PDF Analysis

Presents the zaia usage as premium feature

ZAIA

Global: Zendy Plus monthly

Global: Zendy Tools annual

Global: Zendy Tools monthly

Global: Zendy Free Plan

The sigma receptor is a unique receptor family that has two subtypes: sigma1 and sigma2. The selective sigma1 ligands are found to have potential usage in central nervous system diseases, while sigma2 selective ligands can play an important role as biomarkers and therapeutic agents of tumor proliferation. Based on two well characterized lead compounds, structural modifications were conducted in order to find new ligands that can bind sigma receptor subtypes with both high affinity and high selectivity; the possibility of new ligands as potential SPECT imaging agents was also explored.

The effects of structural modifications on sigma receptor binding