Definition of VPU sensitivity using a model VPU target and role of hydrophobicity of the membrane spanning domain in the viral envelope glycoprotein fusogenicity | Zendy

Sanath Kumar Janaka | Zendy

Open Access

Definition of VPU sensitivity using a model VPU target and role of hydrophobicity of the membrane spanning domain in the viral envelope glycoprotein fusogenicity

Author(s) -

Sanath Kumar Janaka

Publication year - 2013

Publication title -

mospace institutional repository (university of missouri)

Language(s) - English

Resource type - Dissertations/theses

DOI - 10.32469/10355/43241

Subject(s) - glycoprotein , envelope (radar) , domain (mathematical analysis) , sensitivity (control systems) , membrane , viral envelope , microbiology and biotechnology , chemistry , biophysics , biology , engineering , biochemistry , aerospace engineering , mathematics , electronic engineering , mathematical analysis , radar

Retroviral compatibility with diverse glycoproteins has been known and identified through the course of several studies. However, molecular mechanisms of glycoprotein acquisition are poorly defined. Glycoproteins are acquired by the virus as it buds out of the cell at the plasma membrane. Budding of retroviruses involves multilple interactions between viral and cellular proteins and a mature viral particle is the consummation of a regulated and a sequential process. Currently there are no drugs to target the assembly step of retrovirus.

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