Uncovering morphoproteomic relationships using probabilistic graphical models and resource description framework knowledgebases

The heterogeneity of individual patient responses to conventional drug therapies is one of the central problems in personalized medicine and has great impact on clinical outcomes. To address this problem a new field of morphoproteomics was recently introduced. Morphoproteomics is a new method aimed at comprehensive analysis of protein circuitries in diseased cells to design effective drug therapies for individual patient cases. However, due to the overwhelming amount of molecular information that needs to be processed, successful adoption of morphoproteomics will greatly depend on availability of a comprehensive computerized knowledgebase and intelligent retrieval technologies.