An investigation of 8-hydroxy-2’-deoxyguanosine and 8-iso-prostaglandin F2α levels in patients with larynx carcinoma | Zendy

Yaser Said Çetin | Zendy; Ufuk Düzenli | Zendy; Mehmet Berköz | Zendy; Hüseyin Özkan | Zendy; Nazım Bozan | Zendy

AI Assistant Blog Pricing

Home ZAIA Blog

Open Access

An investigation of 8-hydroxy-2’-deoxyguanosine and 8-iso-prostaglandin F2α levels in patients with larynx carcinoma

Author(s) -

Yaser Said Çetin,

Ufuk Düzenli,

Mehmet Berköz,

Hüseyin Özkan,

Nazım Bozan

Publication year - 2020

Publication title -

ent updates

Language(s) - English

Resource type - Journals

ISSN - 2149-7109

DOI - 10.32448/entupdates.744725

Subject(s) - prostaglandin , oxidative stress , deoxyguanosine , larynx , carcinoma , 8 hydroxy 2' deoxyguanosine , chemistry , medicine , endocrinology , anatomy , oxidative damage , dna oxidation

Methods: A total of 50 patients, consisting of 25 patients with larynx carcinoma (study group) and 25 healthy subjects (control group), were enrolled in the present study. Serum 8-OHdG concentration was measured using an ELISA kit, whereas an enzyme immunoassay kit was utilized for the measurement of serum 8-iso-PGF 2α levels. TNM stages of the patients were recorded from the patient records in the study group. Results: 8-OHdG and 8-iso-PGF2α levels were significantly higher in patients with larynx carcinoma than the control subjects. 8-OHdG levels were significantly higher in patients with LN metastases than the patients without LN metastases in the study group.

The content you want is available to Zendy users.

Already have an account? Click here to sign in.

Having issues? You can contact us here

Accelerating Research