Different Alterations of Agonist and Antagonist Binding to 5-HT1A Receptor in a Rat Model of Parkinson’s Disease and Levodopa-Induced Dyskinesia: A MicroPET Study | Zendy

Benjamin Vidal | Zendy; Elise Levigoureux | Zendy; Sarah Chaïb | Zendy; Caroline Bouillot | Zendy; Thierry Billard | Zendy; Adrian NewmanTancredi | Zendy; Luc Zimmer | Zendy

Open Access

Different Alterations of Agonist and Antagonist Binding to 5-HT1A Receptor in a Rat Model of Parkinson’s Disease and Levodopa-Induced Dyskinesia: A MicroPET Study

Author(s) -

Benjamin Vidal,

Elise Levigoureux,

Sarah Chaïb,

Caroline Bouillot,

Thierry Billard,

Adrian NewmanTancredi,

Luc Zimmer

Publication year - 2021

Publication title -

journal of parkinson s disease

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.747

H-Index - 45

eISSN - 1877-718X

pISSN - 1877-7171

DOI - 10.3233/jpd-212580

Subject(s) - dyskinesia , agonist , levodopa , parkinson's disease , medicine , neuroscience , serotonergic , endocrinology , psychology , pharmacology , receptor , serotonin , disease

The gold-standard treatment for Parkinson's disease is L-DOPA, which in the long term often leads to levodopa-induced dyskinesia. Serotonergic neurons are partially responsible for this, by converting L-DOPA into dopamine leading to its uncontrolled release as a "false neurotransmitter". The stimulation of 5-HT1A receptors can reduce involuntary movements but this mechanism is poorly understood.

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