Open AccessCharacterization of the Contribution of Genetic Background and Gender to Disease Progression in the SOD1 G93A Mouse Model of Amyotrophic Lateral Sclerosis: A Meta-Analysis
Author(s) -
Stephen Pfohl,
Martin Halicek,
Cassie S. Mitchell
Publication year - 2015
Publication title -
journal of neuromuscular diseases
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.366
H-Index - 23
eISSN - 2214-3602
pISSN - 2214-3599
DOI - 10.3233/jnd-140068
Subject(s) - amyotrophic lateral sclerosis , sod1 , medicine , disease , genetic model , age of onset , biology , genetics , gene
The SOD1 G93A mouse model of amyotrophic lateral sclerosis (ALS) is the most frequently used model to examine ALS pathophysiology. There is a lack of homogeneity in usage of the SOD1 G93A mouse, including differences in genetic background and gender, which could confound the field's results.
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