Correlations Between Mutant Huntingtin Aggregates and Behavioral Changes in R6/1 Mice | Zendy

Magali Cabanas | Zendy; Marion Piquemal | Zendy; Cristiana Pistono | Zendy; Syndelle Arnaud | Zendy; Divyangana Rakesh | Zendy; Elodie Poinama | Zendy; JeanLouis Guillou | Zendy; Maurice Garret | Zendy; Yoon H. Cho | Zendy

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Correlations Between Mutant Huntingtin Aggregates and Behavioral Changes in R6/1 Mice

Author(s) -

Magali Cabanas,

Marion Piquemal,

Cristiana Pistono,

Syndelle Arnaud,

Divyangana Rakesh,

Elodie Poinama,

JeanLouis Guillou,

Maurice Garret,

Yoon H. Cho

Publication year - 2019

Publication title -

journal of huntington s disease

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.081

H-Index - 24

eISSN - 1879-6400

pISSN - 1879-6397

DOI - 10.3233/jhd-190352

Subject(s) - huntingtin , mutant , huntington's disease , huntingtin protein , biology , microbiology and biotechnology , neuroscience , genetics , gene , medicine , disease

Huntington's disease (HD) is a neurodegenerative disorder caused by the expansion of the trinucleotide CAG in the HD gene. While the presence of nuclear aggregates of mutant huntingtin (mHtt) in neurons is a hallmark of HD, the reason behind its toxicity remains elusive.

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