Open AccessA High Fat/Cholesterol Diet Recapitulates Some Alzheimer’s Disease-Like Features in Mice: Focus on Hippocampal Mitochondrial Dysfunction
Author(s) -
Gianni Mancini,
Cândida Dias,
Cátia F. Lourenço,
João Laranjinha,
Andreza Fabro de,
Ana Ledo
Publication year - 2021
Publication title -
journal of alzheimer s disease
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.677
H-Index - 139
eISSN - 1875-8908
pISSN - 1387-2877
DOI - 10.3233/jad-210122
Subject(s) - medicine , cholesterol , endocrinology , hippocampus , astrocyte , central nervous system
Ample evidence from clinical and pre-clinical studies suggests mid-life hypercholesterolemia as a risk factor for developing Alzheimer's disease (AD) at a later age. Hypercholesterolemia induced by dietary habits can lead to vascular perturbations that increase the risk of developing sporadic AD.
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