Inflammation in Alzheimer’s Disease: Do Sex and APOE Matter? | Zendy

Paula DuarteGuterman | Zendy; Arianne Albert | Zendy; Amy M. Inkster | Zendy; Cindy K. Barha | Zendy; Liisa A.M. Galea | Zendy

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Inflammation in Alzheimer’s Disease: Do Sex and APOE Matter?

Author(s) -

Paula DuarteGuterman,

Arianne Albert,

Amy M. Inkster,

Cindy K. Barha,

Liisa A.M. Galea

Publication year - 2020

Publication title -

journal of alzheimer s disease

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.677

H-Index - 139

eISSN - 1875-8908

pISSN - 1387-2877

DOI - 10.3233/jad-200982

Subject(s) - inflammation , apolipoprotein e , disease , alzheimer's disease , medicine , psychology , neuroscience

Alzheimer's disease (AD) disproportionately affects females with steeper cognitive decline and more neuropathology compared to males, which is exacerbated in females carrying the APOEɛ4 allele. The risk of developing AD is also higher in female APOEɛ4 carriers in earlier age groups (aged 65-75), and the progression from cognitively normal to mild cognitive impairment (MCI) and to AD may be influenced by sex. Inflammation is observed in AD and is related to aging, stress, and neuroplasticity, and although studies are scarce, sex differences are noted in inflammation.

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