Cognitive Improvements After Intermittent Deep Brain Stimulation of the Nucleus Basalis of Meynert in a Transgenic Rat Model for Alzheimer’s Disease: A Preliminary Approach | Zendy

Philippos Koulousakis | Zendy; Daniël van den Hove | Zendy; Veerle VisserVandewalle | Zendy; Thibaut Sesia | Zendy

Open Access

Cognitive Improvements After Intermittent Deep Brain Stimulation of the Nucleus Basalis of Meynert in a Transgenic Rat Model for Alzheimer’s Disease: A Preliminary Approach

Author(s) -

Philippos Koulousakis,

Daniël van den Hove,

Veerle VisserVandewalle,

Thibaut Sesia

Publication year - 2019

Publication title -

journal of alzheimer s disease

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.677

H-Index - 139

eISSN - 1875-8908

pISSN - 1387-2877

DOI - 10.3233/jad-190919

Subject(s) - nucleus basalis , deep brain stimulation , stimulation , neuroscience , psychology , cognition , medicine , disease , cholinergic neuron , central nervous system , parkinson's disease

Deep brain stimulation (DBS) of the nucleus basalis of Meynert (NBM) has been shown to exert promising therapeutical effects in a pilot study with patients suffering from Alzheimer's disease (AD). We aimed at comparing the cognitive effects of intermittent and continuous NBM stimulation paradigms in an animal model for AD. In this exploratory study, aged Tgf344-AD rats were behaviorally tested pre-, and post implantation, while being stimulated with unilateral- or bilateral-intermittent and bilateral-continuous patterns. Bilateral-intermittent NBM DBS lead to supernormal performance in a spatial memory task. These findings suggest that NBM DBS could be further refined, thereby improving patient care.

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