Parietal Involvement in the Semantic Variant of Primary Progressive Aphasia with Alzheimer’s Disease Cerebrospinal Fluid Profile | Zendy

G. Béra | Zendy; Raffaella Migliaccio | Zendy; Thibaut Michelin | Zendy; Foudil Lamari | Zendy; Sophie Ferrieux | Zendy; Marie Nogues | Zendy; Hugo Bertín | Zendy; Marie Odile Habert | Zendy; Bruno Dubois | Zendy; Marc Teichmann | Zendy; Aurélie Kas | Zendy

Open Access

Parietal Involvement in the Semantic Variant of Primary Progressive Aphasia with Alzheimer’s Disease Cerebrospinal Fluid Profile

Author(s) -

G. Béra,

Raffaella Migliaccio,

Thibaut Michelin,

Foudil Lamari,

Sophie Ferrieux,

Marie Nogues,

Hugo Bertín,

Marie Odile Habert,

Bruno Dubois,

Marc Teichmann,

Aurélie Kas

Publication year - 2018

Publication title -

journal of alzheimer s disease

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.677

H-Index - 139

eISSN - 1875-8908

pISSN - 1387-2877

DOI - 10.3233/jad-180087

Subject(s) - primary progressive aphasia , cerebrospinal fluid , aphasia , disease , medicine , pathology , primary (astronomy) , psychology , neuroscience , dementia , physics , frontotemporal dementia , astronomy

Semantic variant of primary progressive aphasia (svPPA) is typically associated with non-Alzheimer's disease (AD) pathology. However, some anatomopathological studies have found AD lesions in those patients. We compared brain perfusion SPECT of 18 svPPA patients with cerebrospinal fluid (CSF) biomarkers indicative of non-AD pathology (svPPA-nonAD) and three svPPA patients with CSF biomarkers indicative of underlying AD (svPPA-AD). All svPPA patients had severe left temporopolar hypoperfusion. SvPPA-nonAD had additional anterior cingulate and mediofrontal hypoperfusion, whereas svPPA-AD had greater left parietal and posterior cingulate involvement. Parietal damage in svPPA constitutes a biomarker for underlying Alzheimer pathology thus refining the classification of this PPA variant.

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