Cerebrospinal Fluid Aβ42/Aβ40 as a Means to Limiting Tube- and Storage-Dependent Pre-Analytical Variability in Clinical Setting | Zendy

Christelle Gervaise-Henry | Zendy; Ghassan Watfa | Zendy; Éliane Albuisson | Zendy; Allan Kolodziej | Zendy; B. Dousset | Zendy; JeanLuc Olivier | Zendy; Thérèse Jonveaux | Zendy; Catherine MalaplateArmand | Zendy

Open Access

Cerebrospinal Fluid Aβ42/Aβ40 as a Means to Limiting Tube- and Storage-Dependent Pre-Analytical Variability in Clinical Setting

Author(s) -

Christelle Gervaise-Henry,

Ghassan Watfa,

Éliane Albuisson,

Allan Kolodziej,

B. Dousset,

JeanLuc Olivier,

Thérèse Jonveaux,

Catherine MalaplateArmand

Publication year - 2017

Publication title -

journal of alzheimer s disease

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.677

H-Index - 139

eISSN - 1875-8908

pISSN - 1387-2877

DOI - 10.3233/jad-160865

Subject(s) - cerebrospinal fluid , tube (container) , limiting , clinical practice , chromatography , chemistry , medicine , materials science , composite material , mechanical engineering , family medicine , engineering

Alzheimer's disease (AD) cerebrospinal fluid (CSF) biomarkers have recently been included in the criteria for AD diagnosis. Unfortunately, their wider use in routine and interpretation require more standardization, particularly for the pre-analytical steps. In particular, amyloid-β (Aβ)42 peptide measurement is strongly influenced by the type of collection tube and by repeated freeze/thaw cycles.

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