Prolonged In Vivo Retention of a Cathepsin D Targeted Optical Contrast Agent in a Mouse Model of Alzheimer’s Disease | Zendy

Jonatan Snir | Zendy; Mojmı́r Suchý | Zendy; Keith St. Lawrence | Zendy; Robert H. E. Hudson | Zendy; Stephen Pasternak | Zendy; Robert Bartha | Zendy

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Prolonged In Vivo Retention of a Cathepsin D Targeted Optical Contrast Agent in a Mouse Model of Alzheimer’s Disease

Author(s) -

Jonatan Snir,

Mojmı́r Suchý,

Keith St. Lawrence,

Robert H. E. Hudson,

Stephen Pasternak,

Robert Bartha

Publication year - 2015

Publication title -

journal of alzheimer s disease

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.677

H-Index - 139

eISSN - 1875-8908

pISSN - 1387-2877

DOI - 10.3233/jad-150123

Subject(s) - in vivo , washout , cathepsin d , wild type , cleavage (geology) , chemistry , genetically modified mouse , cathepsin b , cathepsin , transgene , biophysics , biology , biochemistry , medicine , enzyme , mutant , paleontology , microbiology and biotechnology , fracture (geology) , gene

Cathepsin D (CatD) is a lysosomal protease that is elevated early in Alzheimer's disease (AD). We have previously developed a Targeted contrast agent (CA) to detect CatD activity in vivo, consisting of a magnetic resonance imaging/fluorescent moiety linked to a cell penetrating peptide (CPP) by means of a CatD cleavage site and have demonstrated its uptake in the brain of an AD mouse model.

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