Overdiagnosing Vascular Dementia using Structural Brain Imaging for Dementia Work-Up | Zendy

Ellis Niemantsverdriet | Zendy; Bart Feyen | Zendy; Nathalie Le Bastard | Zendy; JeanJacques Martin | Zendy; Johan Goeman | Zendy; Peter Paul De Deyn | Zendy; Sebastiaan Engelborghs | Zendy

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Overdiagnosing Vascular Dementia using Structural Brain Imaging for Dementia Work-Up

Author(s) -

Ellis Niemantsverdriet,

Bart Feyen,

Nathalie Le Bastard,

JeanJacques Martin,

Johan Goeman,

Peter Paul De Deyn,

Sebastiaan Engelborghs

Publication year - 2015

Publication title -

journal of alzheimer s disease

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.677

H-Index - 139

eISSN - 1875-8908

pISSN - 1387-2877

DOI - 10.3233/jad-142103

Subject(s) - overdiagnosis , autopsy , dementia , vascular dementia , medicine , etiology , medical diagnosis , neuroimaging , pathology , disease , psychiatry

Hypothesizing that non-significant cerebrovascular lesions on structural brain imaging lead to overdiagnosis of a vascular etiology of dementia as compared to autopsy-confirmed diagnosis, we set up a study including 71 patients with autopsy-confirmed diagnoses. Forty-two patients in the population (59%) appeared to have definite Alzheimer's disease (AD), whereas 29 (41%) had a non-AD dementia form. The panel clinically diagnosed possible or probable vascular dementia (VaD) in 27 (38%) patients, whereas only five (19%) patients (p = 0.017) had an autopsy-confirmed diagnosis of VaD. Patients with vascular lesions on structural brain imaging were often misdiagnosed as possible or probable VaD as compared to autopsy-confirmed diagnosis.

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