Cholesterol: An evergreen molecule in biology | Zendy

G. Aditya Kumar | Zendy; Amitabha Chattopadhyay | Zendy

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Cholesterol: An evergreen molecule in biology

Author(s) -

G. Aditya Kumar,

Amitabha Chattopadhyay

Publication year - 2016

Publication title -

biomedical spectroscopy and imaging

Language(s) - English

Resource type - Journals

eISSN - 2212-8808

pISSN - 2212-8794

DOI - 10.3233/bsi-160159

Subject(s) - evergreen , biology , cholesterol , computational biology , nanotechnology , ecology , biochemistry , materials science

Cholesterol, an essential component of higher eukaryotic membranes, was discovered more than two centuries ago. The development and progress of cholesterol research in the last 200 years has been truly fascinating, with elements of surprise, serendipity and intrigue. In this review, we trace this journey the way we see it, and follow it up with the role of membrane cholesterol in crucial areas of contemporary research (transbilayer domains, regulation of GPCR function and role in the entry of intracellular pathogens into host cells), with considerable footprint from our work. We believe that cholesterol will continue to surprise and fascinate future researchers, thereby justifying its evergreen nature.

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