Experimental models of stress | Zendy

Vladimir K. Patchev | Zendy; Alexandre V. Patchev | Zendy

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Experimental models of stress

Author(s) -

Vladimir K. Patchev,

Alexandre V. Patchev

Publication year - 2006

Publication title -

dialogues in clinical neuroscience

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.11

H-Index - 87

eISSN - 1958-5969

pISSN - 1294-8322

DOI - 10.31887/dcns.2006.8.4/vpatchev

Subject(s) - stressor , neurochemical , neuroscience , fight or flight response , translational research , psychology , disease , stress (linguistics) , cognitive psychology , cognitive science , medicine , biology , pathology , linguistics , philosophy , gene , biochemistry

Illustrating the complexity of the stress response and its multifaceted manifestations is the leading idea of this overview of experimental paradigms used for stress induction in laboratory animals. The description of key features of models based on naturalistic stressors, pharmacological challenges, and genomic manipulations is complemented by comprehensive analysis of physiological, behavioral, neurochemical, and endocrine changes and their appropriatness as outcome readouts. Particular attention has been paid to the role of sex and age as determinants of the dynamics of the stress response. Possible translational applications of stress-inducing paradigms as models of disease are briefly sketched.

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