ANTIOXIDANT AND ANTIHYPERURICEMIC POTENTIALS OF RARU (Cotylelobium melanoxylon Pierre) BARK

Raru (Cotylelobium melanoxylon Pierre) bark has been used in the production of traditional alcoholic beverages (called as tuak), especially in North Sumatera, Indonesia. The objective of this research was to evaluate the potency of C. melanoxylon P. bark as an antioxidant and antihyperuricemic. Methanolic extract of C. melanoxylon P. bark was obtained through the maceration process for 48 h with a yield of 55.2%. The result of phytochemical screening of C. melanoxylon P. bark methanolic extract revealed the presence of several secondary metabolites, i.e. flavonoid, saponin, tannin, and terpenoid. The methanolic extract of C. melanoxylon P. bark exhibited an exceptional antioxidant activity (IC50 = 46.44 ppm) that determined using DPPH method. This methanolic extract also showed a significant antihyperuricemic activity in male mice that had been induced using chicken liver (CL) 1.25g/Kg, 2.5 g/Kg and 5 g/Kg of body weight. Based on the result, the methanolic extract of C. melanoxylon P. bark might have great potential as an antioxidant and antihyperuricemic agent.