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A highly efficient novel method for the synthesis of β-amino ketones via a one-pot three-component Mannich reaction in the presence of silica nanoparticles (SNPs) under microwave (MW) irradiation is described. The formation of both C-C and C-N bonds occurs through a multicomponent reaction (MCR) of an enolizable carbonyl compound with an imine intermediate generated from the condensation of amine and aldehyde, yielded the title compound, which was structurally characterized, in high yields. The noteworthy features of the present protocol include simple substrate material, low catalyst loading, remarkable catalytic performance, solvent-free reaction conditions, clean reaction profile, shorter reaction time, recyclability of catalyst, an excellent yield of β-amino carbonyl compounds without any by-products.

MICROWAVE-ASSISTED MULTI-COMPONENT SYNTHESIS OF β-AMINO KETONES VIA MANNICH REACTION APPROACH USING HETEROGENEOUS SNPs CATALYSTS