SYNTHESIS, CHARACTERIZATION, SPECTRAL STUDIES AND ANTIMICROBIAL APPLICATION OF LIGAND N2 , N6 -BIS (5-NITROTHIAZOL-2-YL) PYRIDINE 2, 6-DICARBOXAMIDE AND ITS COMPLEXES OF Cu(II), Ni(II) and Fe(III)

The ligand N,N-bis(5-Nitrothiazol-2-yl)pyridine 2, 6-dicarboxamide ligand was synthesized by the reaction of pyridine 2,6 dicarboxylic acid and 2-amino 5-nitro thiazole. The synthesized ligand was reacted in THF with salts of metal (Cu, Ni and Fe) to form complexes. Deprotonated ligand shows tridentate nature and coordinates to metal ion to form pincer cavity. In all Complexes, metals were surrounded by three nitrogen atoms and other sites coordinated by other groups (Chloride, Acetate). All the synthesized complexes were characterized by spectroscopic techniques and physical measurementslike UV Visible, 13C NMR, and 1H NMR, IR spectroscopy, DSC and elemental analysis and molar conductance measurements. The ligand and its complexes were tested for antimicrobial activity against bacterial and fungal strains by determining inhibition zone, minimal inhibitory concentration (MIC) and minimal bactericidal concentration (MBC). The complexes showed moderate antimicrobial activity when tested against bacterial strains